SUMOylation regulates kainate-receptor-mediated synaptic transmission

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منابع مشابه

KAINATE RECEPTOR-MEDIATED SYNAPTIC TRANSMISSION IN THE ADULT ANTERIOR CINGULATE CORTEX Abbreviated title: Forebrain kainate receptor-mediated synaptic transmission

Acknowledgements: Supported by grants from NINDS NS42722, the Canadian Institutes of Health Research, the EJLB-CIHR Michael Smith Chair in Neurosciences and Mental Health, and the Canada Research Chair to M Zhuo. We would like to thank Drs. Stephen F. Heinemann for kindly providing GluR5 and GluR6 KO mice, John F. MacDonald and Geoffrey T. Swanson for providing GYKI 53655 and Michele J. Petrovi...

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Long-Term Depression of Kainate Receptor-Mediated Synaptic Transmission

Kainate receptors (KARs) have been shown to be involved in hippocampal mossy fiber long-term potentiation (LTP); however, it is not known if KARs are involved in the induction or expression of long-term depression (LTD), the other major form of long-term synaptic plasticity. Here we describe LTD of KAR-mediated synaptic transmission (EPSC(KA) LTD) in perirhinal cortex layer II/III neurons that ...

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Ubiquitin ligase RNF167 regulates AMPA receptor-mediated synaptic transmission.

AMPA receptors (AMPARs) mediate the majority of fast excitatory neurotransmission, and their density at postsynaptic sites determines synaptic strength. Ubiquitination is a posttranslational modification that dynamically regulates the synaptic expression of many proteins. However, very few of the ubiquitinating enzymes implicated in the process have been identified. In a screen to identify tran...

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Kainate receptors and synaptic transmission.

Excitatory glutamatergic transmission involves a variety of different receptor types, each with distinct properties and functions. Physiological studies have identified both post- and presynaptic roles for kainate receptors, which are a subtype of the ionotropic glutamate receptors. Kainate receptors contribute to excitatory postsynaptic currents in many regions of the central nervous system in...

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Kainate receptor-mediated synaptic transmission in the adult anterior cingulate cortex.

Kainate (KA) receptors are expressed widely in the CNS. However, little is known about their functional characterization, molecular identity, and role in synaptic transmission in the forebrain of adult mice. Patch-clamp recordings in genetically modified mice show that postsynaptic KA receptors contribute to fast synaptic transmission in pyramidal neurons in the anterior cingulate cortex (ACC),...

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ژورنال

عنوان ژورنال: Nature

سال: 2007

ISSN: 0028-0836,1476-4687

DOI: 10.1038/nature05736